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Many factors lead to the frustrating cycle of weight gain and weight loss – but the driving force can be to keep fat cells that are A Memory of obesity.
This emerges from a recently published study, which was first published in the Nature magazine last autumn.
Researchers say that fat cells influence the abnormal metabolic pathways in the body long after sales of pounds, which makes it more likely that people regain weight.
The study compares Zepbound and Wegovy for weight loss results
Study results
The team of Swiss scientists was curious about whether Weight regain After losing weight, “metabolic memory” is due, in which the body remembers and endeavors to return to its earlier state of obesity.
Many factors lead to the frustrating cycle of weight gain and weight loss – but the driving force can be that fat cells retain a memory of obesity. (IStock)
They analyzed chemical markers on fat cells in mice that a high -fat diet was fed. When the researchers next, when the mice were only fed with a standard meal, analyzed their adipose tissue after the creation of studies.
The team then compared these rehearsals with a lean mouse group that was fed A Standard meal To determine whether the chemical markers were connected to unhealthy changes in the body on the fat cells.
The mice on the high -fat diet continued to have unhealthy changes in their metabolism, including a stronger difficulty in regulating sugar metabolism, more inflammation and abnormal fat storage.
Mice that were previously obese gained faster compared to the control group after they had eaten a high-fat diet what to point out to a persistent impairment of the metabolism Lose weightthe researchers found.
Mice that were previously obese gained faster compared to the control group after they had eaten a high-fat diet-what indicates a persistent impairment of the metabolism after losing weight. (IStock)
The study also examined human rehearsals and analyzed how the genes in fat cells can lead to unhealthy changes in the body, as they did in mice.
The researchers analyzed the fat tissue of the participants and after they had undergone a bariatric operation, and compared them to the fat cells of lean people who had no obesity in the history.
“This latest research suggests that after the loss of weight its fat cells do not completely return to ‘normal’.”
In the case of obese individuals, the genes from fat cells continued to work abnormally in the body, which led to more inflammation and metabolic problems two years after losing weight.
A restriction of the study is that it only examined one type of cell cells – fat cells. Further studies are required to determine whether other cells or tissue in the body also have a memory of being overweight, the researchers entered.
‘Complex mixture’ of factors
In fact, fat cells have a memory of being obese, which can make it easier to regain weight and stay in a state that promotes inflammation and metabolic problems, confirmed Gretchen Zimmermann, a registered nutritionist and vice president for clinical strategy at VIDA Health, a virtual obesity provider. (It wasn’t part of the study.)
“This latest research suggests that after the loss of weight your fat cells do not completely return to ‘normal’,” Zimmermann told Fox News Digital.
The researchers analyzed the fat tissue of the participants and after they had undergone a bariatric operation, and compared them to the fat cells of lean people who had no obesity in the history. (IStock)
But while biology plays a crucial role in obesity, it didn’t warn everything, she warned.
“A complex mix of genetics, biology, environment, psychology, medication and social determinants shape obesity, ”said Zimmermann.
“Move on, eat real food and build muscle.”
Healthy habits can counteract genetics that promote weight gain.
Ideally, said the expert, this included a combination of physical activity (including strength training), a sufficient amount of protein and fiber as well as phytonutrients of plants that counteract oxidative stress and chronic inflammation, according to Zimmermann.
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“Move, eat real food and build muscle,” she said.
“These behaviors reduce the inflammation, improve blood sugar control, contribute to a healthy microbiome and protect the metabolism – even if the weight does not decrease or remains the same.”
Researchers say that healthy habits can counteract genetics that promote weight gain. (IStock)
For some, however, the underlying problem may sleep in EpigeneticsWhat includes how the behavior and surrounding environment influence a person, how genes work in the body, according to the centers for the control and prevention of diseases.
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“Obesity is a chronic relapse state that has an epigenetic thing”, Dr. Caroline Apovian, Professor of Medicine at the Harvard Medical School and co-director of the Center for Weight Management and Wellness at the Brigham and Women’s Hospital, told Fox News Digital.
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People who are more susceptible to save calories may have more difficult to lose weight and to hold it out Diet and movementCompared to those who may have a easier time, according to Apovian, who was not involved in the study.
Fox News Digital turned to the authors of the study for a comment.
