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A new weekly injectable drug could change the life of more than eight million people who live with life Parkinson’s diseasePotentially replace the need for daily pills.
Scientists from the University of South Australia (Unisa) developed a long-acting injectable wording that provides two important Parkinson’s medication for a whole week.
There is currently no cure for Parkinson’s, the second most common neurological disorder that, according to the Parkinson’s Foundation, affects more than a million Americans.
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In order to treat symptoms such as tremors, rigidity and slow movement, patients normally take daily Oral medicationLike Levodopa and Carbidopa after the university press release.
This method can be particularly difficult for people who have difficulty taking pills consistently, which leads to irregular medication mirrors, increased side effects and reduced effectiveness.
Scientists from the University of South Australia developed a long-acting injectable formulation that provides two important Parkinson’s medication for a whole week. (IStock)
Levodopa is the “gold standard therapy for Parkinson’s”, said the senior researcher Professor Sanjay Garg at the Unisa, but his short lifespan has to be taken several times a day.
The researchers tested an injectable gel implant that combines a biodegradable substance approved by the FDA with a pH sensitive substance in order to achieve a controlled and persistent drug release.
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The gel is injected under the skin or muscle tissue by a single shot, which means that no surgical implant is required, and the symptoms are minimal, as they found.
The team found that the gel gradually released the Key Parkinson’s medication (90% of the Levodopa drug and 81% of Carbidopa) during a week.
The results were published in the magazine Drug Delivery and Translational Research.
In order to treat symptoms such as tremors, rigidness and slow movement, patients usually take daily oral medication. (IStock)
“The reduction of the dosage from several times a day to a weekly injection is an important step forward in Parkinson’s therapy,” said Garg in the press release. “We not only improve how the medication is handed over. Improvement of the patient’s life. “
Extensive laboratory tests confirmed the effectiveness and safety of the system.
“We not only improve how the medication is given. We improve the life of the patients.”
The implant degraded by over 80% within a week and showed no significant toxicity in the living capacity tests of cells.
“The effects of this research are profound,” added Garg.
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Deepa Nakmode, a doctoral student at the University of South Australia, found that this method is steadily released for over a week, levodopa and carbidopa, with consistent plasma levels maintained and the risks associated with fluctuating drug concentrations were reduced.
“After years of focused researchIt is incredibly worthwhile to see how our innovation reach this phase for long-acting injections for Parkinson’s disease, ”he said in the publication.
The invention of the team was now submitted for an Australian patent, added Nakmode.
Extensive laboratory tests confirmed the effectiveness and safety of the new drug, the researchers found. (IStock)
The technology could also be adapted for other chronic diseases, like cancerDiabetes, neurodegenerative diseases, chronic pain and infections, which according to Garg require long -term pharmaceutical levy.
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The system can be set depending on a few days to several weeks, depending on the therapeutic needs over a period of a few days.
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Scientists hope to start clinical studies in the near future and research opportunities to make the gel commercially available.
